For seven types of tumors, where ≥50 samples were available, genes identified as amplified and overexpressed with frequency of ≥10% were MYC (25%) and MET (18%) in colorectal cancer; SKP2 (21%), FOXL2 (18%), EGFR (16% and 14% for variants 3 and 1, respectively) in lung squamous cell carcinoma; HIST1H3B (19%) and MYCN (13%) in liver cancer; and HIST1H3B (12%) in breast cancer. The gene discussed is MYCN; the disease is colorectal cancer.