Genes frequently overexpressed in specific tumors were as follows: ALK in melanoma (50%) as previously reported10; RET [reviewed in ref. 11] (37% for variant 2 and 35% for variant 4), FLT3 (44%) and ERBB212 (34%) in breast cancer; CSF1R (47%), DNMT1 (42%), and MYD88 (31%) in sarcoma; KIT13, 14 (100%), AR (71%), SMO (50%), PDGFRA14 (43%), and BCL215 (variant alpha) (42%) in gastrointestinal stromal tumors (GISTs). The gene discussed is SMO; the disease is breast carcinoma.