Another notable finding was that 21 of 25 samples (84%) with FOXL2 amplification-dependent overexpression were derived from squamous cell carcinoma of the lung (10 of 56), head and neck (9 of 101), and esophagus (2 of 14), and its frequency was 12% of a total of 176 squamous cell carcinoma samples (Supplementary Fig. 3). This evidence concerns the gene FOXL2 and squamous cell lung carcinoma.