However, we found that knockdown of SHP, a well-known FXR target gene mediating several major functions of FXR8, 9, neither affected NSCLC cell proliferation nor caused changes in cyclin D1 or p-Rb expression, indicating, at least in this context, that FXR-induced cell proliferation is SHP independent. Here, NR0B2 is linked to non-small cell lung carcinoma.