In the present study, we determined the alternative splicing of endogenous tau exon 10 in differentiated human neuronal progenitor cells and in Ts65Dn mice, which are a commonly used mouse model of DS and contain one extra copy of Dyrk1A gene, and investigated the role of Dyrk1A in tau exon 10 splicing. This evidence concerns the gene DYRK1A and Dravet syndrome.