TSLP and Alzheimer disease: Overall, increased levels of IL-4, IL-13, IL-25 and IL-33, as well as the keratinocyte-derived factor thymic stromal lymphopoietin (TSLP), a master regulator of Th2-driven inflammation, have been identified in the skin of AD patients, all of which are known to influence keratinocyte function and skin barrier integrity14, 15.