SCN10A and psoriasis: Very interestingly, ablation of nerve‐derived signals results in decreased DCs, IL‐23 expression and improved acanthosis (Ostrowski et al, 2011), and skin TRPV1+Nav1.8+ nociceptors, by interacting with dermal DCs, drive IL‐23 production in IMQ‐induced psoriasis‐like skin disease, strongly supporting the notion that these dermal DCs are very essential skin IL‐23 producers in the pathophysiology of psoriasis (Riol‐Blanco et al, 2014).