In summary, the present study links RIG‐I, an important psoriasis susceptibility gene, with the abnormal activation of NF‐κB and excessive production of IL‐23 in psoriatic lesions and suggests that RIG‐I, a major cytoplasmic sensor of antiviral immunity, is one of the dominant pathological factors in psoriasis. Here, NFKB1 is linked to psoriasis.