Increasing evidence indicates that genetic mutations in genes such as TNFAIP3, TNIP1, NFKBIA, TRAF3IP2, and CARD14 result in an impaired negative regulation of NF‐κB proinflammatory activity leading to psoriasis (Nair et al, 2009; Huffmeier et al, 2010; Strange et al, 2010; Jordan et al, 2012). The gene discussed is TNIP1; the disease is psoriasis.