By quantitative real‐time polymerase chain reaction (qPCR) and immunohistochemistry analysis, we detected that RIG‐I expression was significantly increased in lesional skin of patients with psoriasis, and the up‐regulation of RIG‐I was confined to the epidermal keratinocytes and the dermal inflammatory cells (Fig 3A–C). The gene discussed is RIGI; the disease is psoriasis.