To specifically investigate the contribution of RIG‐I‐mediated antiviral signaling in psoriasis‐like skin inflammation, we injected 5′ppp‐dsRNA (complexed with the cationic lipid LyoVecTM, 5′ppp‐dsRNA) or 5′ppp‐dsRNA control (complexed with the cationic lipid LyoVecTM, dsRNA Ctr) into the ears of wild‐type (WT) mice on every second day for 2 weeks. This evidence concerns the gene RIGI and psoriasis.