Taken together, our data reveal that mice lacking RIG‐I display a decreased severity of key disease features including IL‐23 and IL‐17 production, and highlight that RIG‐I might play a pivotal role in the keratinocyte proliferation and the epidermal hyperplasia in IL‐23‐ and IMQ‐induced psoriasis‐like mouse models. The gene discussed is IL17A; the disease is psoriasis.