Therefore, our data indicate that the RIG‐I‐mediated antiviral response is pivotal for the IL‐23 production in the DCs and for the IL‐23‐ and IMQ‐induced psoriasis‐like skin inflammation in mice, highlighting that the dysregulation in the antiviral immune responses of hosts through the innate pattern recognition receptors may initiate the chronic skin inflammation in psoriasis. The gene discussed is IL23A; the disease is psoriasis.