UCP1 and type 2 diabetes mellitus: Also, rosiglitazone triggered lipid turnover and hypolipidemic actions by rapid browning of WAT in EAT depots of obese/T2DM rats by upregulation of PRDM-16, UCP-1 and mitochondrial biogenesis factors (i.e., PGC-1α, COX-4) [99] (Fig. 2).