Unfortunately, some of them (i.e., dexfenfluramine, fenfluramine, sibutramine) have been withdrawn from market because of cardiotoxic side effects [98] Similarly, a PPARγ activator (pioglitazone) was associated with a reduction of pro-inflammatory genes as IL-1β in EAT from T2DM patients with CAD [29]. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.