IrAEs associated with PD-1 blockade therapy include interstitial pneumonitis, colitis with gastrointestinal perforation, type 1 diabetes, severe skin reactions, immune thrombocytopenia, neutropenia and sepsis after corticosteroid therapy, encephalopathy and neurological sequelae, Guillain-Barré syndrome, myelitis, myasthenia gravis, myocarditis and cardiac insufficiency, acute adrenal insufficiency, and nephritis [84–87]. The gene discussed is PDCD1; the disease is type 1 diabetes mellitus.