Migratory and metastatic behavior of cancer cells can be further influenced by the lysyl oxidase-like 4 protein (LOXL4), an enzyme that is highly involved in the biogenesis of connective tissue and matrix re-modelling [41] and which has been identified as a protein in TGFBR2 expressing cell-derived exosomes. This evidence concerns the gene TGFBR2 and cancer.