Diabetic ketoacidosis (DKA) represents a profound insulin deficient state leading to hyperglycemia (>200 mg/dl) and acidosis (serum pH < 7.3, HCO3 < 15 mEq/L), along with accumulation of keto-acids in the blood, dehydration, electrolyte loss, and hyperosmolality [1]. The gene discussed is INS; the disease is Hyperglycemia.