CLDN4 and neoplasm: Moreover, among the 50 proteins, 12 proteins (3 up-expressed, 9 down-expressed) are closely related to tumour growth and metastasis: 5′-nucleotidase domain-containing protein 3, cathepsin, Napor protein (up-expressed); high mobility group protein B2, eukaryotic translation initiation factor 4H isoform 2/(EIF4H), transcriptional activator protein Pur-alpha, claudin-4, casein kinase II alpha 1 subunit, cytochrome b-c1 complex subunit 2, cleavage stimulation factor subunit 2, ER membrane protein complex subunit 1 isoform X2, and nuclear receptor coactivator 5 (down-expressed).