Clinically, overexpression of HOTAIR is a powerful predictor of overall survival and progression for several cancers including gastrointestinal stromal tumors [20], breast cancer [21], squamous cell carcinoma [22], nasopharyngeal carcinoma laryngeal [23], colon cancer [24], hepatocellular carcinoma [25, 26] and pancreatic cancer [27]. Here, HOTAIR is linked to squamous cell carcinoma.