AKT1 and Hyperglycemia: Conversely, Baranyai et al. showed that a longer period of hyperglycemia (35 vs. 20 min in the present protocol) before ischemia led to increased pAkt levels and the activation of the Akt-the mechanistic target of rapamycin (mTOR) pathway [12] suggesting that the duration of hyperglycemia may be also important.