The vast amount of genomic and molecular data generated recently has proved that medulloblastoma is not a single entity but is composed of at least four subtypes: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and Group 4 (non-WNT/SHH types), with distinct genetic and biological profiles as well as different course of disease requiring adequate therapeutic approaches [2–6]. The gene discussed is SHH; the disease is medulloblastoma.