For example, the BRCA1 carriers at the 90th percentile of the ER-negative breast cancer PRS had an estimated breast cancer risk of 19% by age 40 years and 39% by age 50 years, compared with 5% by age 40 years and 21% by age 50 years for carriers at the 10th percentile of the PRS. The gene discussed is BRCA1; the disease is breast cancer.