The ages at which women with BRCA1 mutations would reach a cumulative risk of ovarian cancer of 2.8% are 48 years for those at the 1st percentile of the PRS, and 46, 45, 44, and 43 years for those at the 5th, 10th, 20th, and 30th percentiles of the PRS, respectively. The gene discussed is BRCA1; the disease is ovarian cancer.