Moreover, we demonstrated that silencing LRG1 expression led to the significant down-regulation of cell cycle genes, including cyclin D1, B, and E, which have been reported to play crucial roles in the transition of the G1/S phase during cell proliferation and the cell cycle[29] and the over-expression of these genes lead to a shortened G1 phase and accelerated tumour formation [30]. Here, LRG1 is linked to neoplasm.