FGFR4 and cancer: Moreover, FGFR4 overexpression is associated with metastasis, late stages and poor prognosis in colorectal, gastric, lung, breast adenocarcinoma, rhabdomyosarcoma and high-grade serous ovarian carcinoma [6, 8, 9] and probably contribute to the progression of cancer by regulating proliferation and anti-apoptosis.