Moreover, secretion of CXCL10 was increased in supernatants of 4T1 breast tumor cells in which nuclear IP3 was buffered, but it was unaffected in ΔIP3-NLS infected cells (control = 1.3 ± 0.2 pg/mL; ΔIP3-NLS = 1.7 ± 0.2 pg/mL; IP3-sponge-NLS = 5.4 ± 0.6 pg/mL (Fig 6B). Here, CXCL10 is linked to breast neoplasm.