Moreover, in vivo nuclear IP3 buffering also suppressed tumor cell proliferation as shown by the reduced number of PCNA positive cells per μm2 subjected to IP3-sponge-NLS treatment (control = 2796 ± 338 cells; IP3-sponge-NLS = 1583 ± 112 cells), (Fig 3C and 3D). This evidence concerns the gene PCNA and neoplasm.