To better understand the cytokine profile, we calculated the associations between cytokines and observed that HAM/TSP patients had a higher number of correlations than asymptomatic patients, indicating that new correlations were formed in the HAM/TSP patients (IFNᶌ vs TNFα, IL-10, IL6, IL4 and PVL; IL17 vs IL6 and PVL; IL2 vs TNF α, IL4, IL10 and PVL). This evidence concerns the gene TNF and periventricular leukomalacia.