Identified Tcf4 target genes, which are misregulated on Tcf4 knockdown and bound by Tcf4 (Supplementary Table 12), include 71 ID genes, 210 genes de novo mutated in ASD patients and 85 genes de novo mutated in schizophrenia patients and include well-known MD genes Foxp2, Shank3 and Syngap1 (Supplementary Table 13). The gene discussed is SHANK3; the disease is schizophrenia.