The NO system has been implicated in the treatment,22, 46, 47, 48, 49, 50, 51, 52, 53, 54 as well as the pathobiology of depression.49, 50, 55, 56, 57 We, therefore, further investigated PSD-95, nNOS, CAPON and sGC-β1. The gene discussed is NOS1; the disease is depressive disorder.