Bearing in mind that diffuse large B cell lymphoma is the most frequent lymphoma associated with the germinal center cell of origin, and that limitations of this data (included studies differed in study design, applied cut-offs for MYC overexpression and chemotherapy treatment) did not contribute to high or statistically significant heterogeneity, MYC (over)expression can be regarded as a potential target for precise therapy in MYC-expressed lymphoma entities. Here, MYC is linked to diffuse large B-cell lymphoma.