Inhibition of ATF6 using the protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) to prevent its cleavage and activation or using an ATF6 small interfering RNA prevented Nogo-B induction in PASMCs under ER stress and normalized Nogo-B expression in PAH PASMCs [160,164]. The gene discussed is RTN4; the disease is pulmonary arterial hypertension.