It has been reported that HIF-1α activation in human PAH PASMCs resulted in mitochondrial fission via cyclin B1/CDK1 phosphorylation of DRP1, in comparison to human control PASMCs that could be stimulated to undergo DRP1-mediated fission through chemical activation of HIF-1α [142]. Here, DNM1L is linked to pulmonary arterial hypertension.