PPARGC1A and pulmonary arterial hypertension: The traditional MCT-induced rat model of PAH demonstrated attenuation of PGC1α and SORT3 mRNA levels, which when coupled with the finding that SIRT3 KO mice developed spontaneous PAH, further implicates SIR3 as having a broad regulatory role in the events underpinning PAH metabolic reprogramming [155].