ATP2A2 and pulmonary arterial hypertension: Gene transfer of human SERCA2a using an adeno-associated virus serotype 1 (AAV1.SERCA2a) via aerosolized inhalation in both a MCT-induced rat PAH model and a pulmonary vein banding porcine model demonstrated increased expression of SERCA2 in pulmonary arteries, decreased pulmonary artery pressure, and improved RV function [128,129].