The findings that bryostatin 1, which represses PKC expression, failed to reverse multidrug resistance of human cancer cells [98], and that PMA decreased P-gp activity in teleost renal proximal tubules [99], is conflicting with the assertion that PKC activity is positively correlated with P-gp-mediated transport, or, at least, suggests that it has to be relativized according to the cell type and/or the species [100]. The gene discussed is PRRT2; the disease is cancer.