Investigations in experimental animals are also beginning to unravel the role of FKBP5 in the neurobiology of depression and PTSD: Along with dysregulation of the HPA axis, SPS has been shown to acutely induce FKBP5 mRNA in prefrontal cortex, hippocampus and amygdala in rats 89. Here, FKBP5 is linked to post-traumatic stress disorder.