However, those changes suggested that social stress-induced downregulation of MAP-2 along with Bdnf exon IV might has provoked dendritic or synaptic alterations, leading to cognitive impairments and that chronic agomelatine could exert a protective effect on mice mnemonic functions by preventing Bdnf IV and MAP-2 gene expression deficits. The gene discussed is MAP2; the disease is Cognitive impairment.