IGF1 and Sepsis: Moreover, we also detected high-expression of the canonical M2-associated transcripts, Arg1 (encoding arginase-1) and Mrc1 (encoding mannose receptor, CD206), as well as an up-regulation of the wound healing-related gene Igf1 (encoding IGF-1), in the lung tissues of sepsis-surviving mice by day 10 and 15 after CLP (Fig. 4a).