Notably, deletion of RAGE (but not TLR9) significantly prolonged animal survival (Figure 4A), decreased formation of pancreatic lesions (Figure 4B), increased normal acinar structures (Figure 4B), limited tumor metastasis/invasion to the liver, lung, and kidney (Figure 4C), reduced serum IL-6 levels (Figure 4D), and diminished pancreatic levels of p-ERK1/2 (Figure 4E), p-AKT (Figure 4F) and p-STAT3 (Figure 4G) in KCHR mice compared with KCH mice. Here, TLR9 is linked to neoplasm.