Expression of protein (Supplementary information, Figure S10A and S10B) and mRNA (Supplementary information, Figure S10C) of RAGE and TLR9 (but not TLR2 and TLR4) was increased in the pancreas of KCH mice compared with KC mice, indicating a potential role of RAGE and TLR9 in pancreatic tumorigenesis. The gene discussed is TLR4; the disease is keratoconus.