Indeed, we found that glycyrrhizin treatment prevented PanIN development preserving normal acinar structures (Figure 5E), sustaining nuclear HMGB1 expression (Figure 5F), and decreasing circulating HMGB1 and nucleosome levels (Figure 5G) in the cerulein-mediated accelerated oncogenic K-Ras mouse model of pancreatic cancer. Here, KRAS is linked to pancreatic neoplasm.