Classical side effects of BRAF inhibitors include gastrointestinal symptoms (diarrhea, nausea, vomiting), skin symptoms (cutaneous squamous cell carcinoma, keratoacanthoma, photosensitivity reaction, hyperkeratosis, rash), fatigue, pyrexia, and elevated liver enzymes [23, 42]. This evidence concerns the gene BRAF and cutaneous squamous cell carcinoma.