TCGA data were also used in systematic pan-cancer analyses, revealing a pool of splicing events commonly altered across different cancer types and splicing factors whose expression strongly associates to cancer-specific splicing signatures, such as that of RBFOX2, QKI, PTBP1, MBNL1/2 and CELF2 (Sebestyén et al. 2015, 2016; Tsai et al. 2015; Danan-Gotthold et al. 2015). This evidence concerns the gene PTBP1 and cancer.