PTBP1 and cancer: Several important roles in cancer development have been recently found to be played by other splicing factors, such as the function of FOX2, RBM4, and CELF2 as tumour suppressors (Ramalingam et al. 2012; Wang et al. 2014; Yong et al. 2016), the oncogenic effect of CELF1 (House et al. 2015), or the regulation of SRSF3 splicing patterns by PTBP1 and PTBP2 (Guo et al. 2015).