SLU7 and cancer: More recently, RNA-seq combined with de novo transcriptome assembly in cultured cells infected with the oncogenic human papillomavirus HPV16 revealed the upregulation, in infected cells, of the splicing factor CELF3 as well as several differentially expressed novel human transcripts which appeared associated with well-known cellular pathways altered in cancer such as the MAPK and the VEGF signalling (Xu et al. 2016).