Moreover, AS of the titin gene has been linked to the regulatory activity of RNA binding motif protein 20 (RBM20), described as a regulator of cardiac AS and whose mutations have been associated with human dilated cardiomyopathy (Guo et al. 2012; Maatz et al. 2014; Zhu et al. 2016). The gene discussed is RBM20; the disease is dilated cardiomyopathy.