Nevertheless, KCC2 has been shown important for nervous function, with reduced KCC2 function being associated with several types of pathology, such as neuropathic pain (Coull et al., 2003), epilepsy (Huberfeld et al., 2007), autism (Tyzio et al., 2014; Merner et al., 2015), schizophrenia (Merner et al., 2015), spasticity (Boulenguez et al., 2010), and ischemia (Jaenisch et al., 2010). The gene discussed is SLC12A5; the disease is autism.