Mechanistically, aberrant TNF was suggested to contribute to inducing the evoked expression of DKK-1 and sclerostin in RA, and a neutralization of DKK-1 with antibodies led a reversed phenotype of erosions in several inflammatory arthritis murine models and altered the phenotype from bony erosion to proliferation [62]. The gene discussed is DKK1; the disease is rheumatoid arthritis.