In general, SLE is recognized as a disease that is primarily attributed to autoantibodies, cytokines, and immune complex deposition, and a compelling body of study has demonstrated cytokines such as soluble interleukin-7 receptor (sIL-7R) and autoantibodies to complement C1q, histone, chromatin, and nuclear and double-strand DNA (dsDNA) alone or in combination with anti-C1q, anti-dsDNA, and/or antibodies and/or nucleosome were strongly correlated with renal diseases and could be used for prognosis of patients with LN [2, 4–7]. Here, IL7R is linked to kidney disorder.