Serum concentrations of respective Wnt-3A, FZD-8, and DKK-1 were 45.54 ± 2.24, 4.96 ± 0.22, and 7.32 ± 0.33 ng/mL for healthy subjects; 44.73 ± 1.86, 4.67 ± 0.20, and 14.28 ± 0.53 ng/mL for SLE patients; 53.54 ± 3.44, 5.49 ± 0.25, and 17.02 ± 0.72 ng/mL for LN-SLE patients; and 41.55 ± 2.20, 5.16 ± 0.22, and 12.22 ± 0.55 ng/mL for non-LN patients (Table 3 and Figure 1). This evidence concerns the gene FZD8 and systemic lupus erythematosus.