Such a lack of specificity of anti-dsDNA antibodies for renal flare was also observed in other conventional parameters such as antinuclear antibody (ANA), levels of complements C3 and C4, proteinuria, and urine sediment [9], which thus led to search other reliable biomarkers for identifying SLE patients with active nephritis [10]. Here, C4A is linked to systemic lupus erythematosus.