The relationship between IL-6 and stroke is established principally by neuroinflammatory mechanisms in the CNS, where the expression of genes such as IL-6, besides myeloperoxidase (MPO), IL-1β, and TNF-α, is fundamental for stroke susceptibility [99] but also myocardial stroke generates a peripheral proinflammatory response in skeletal muscle [100]. Here, TNF is linked to Stroke.