In chronic heart failure training muscular exercise reduces muscle production of IL-6, TNF-α, IL-1β, and iNOS [101] although those markers involved in muscle atrophy, that is, atrogin and MuRF1, do not change their expression pattern in skeletal muscle [102], assessing that this model is not fully comparable to stroke-related muscle disorders. The gene discussed is IL1B; the disease is stroke disorder.