The major findings we showed in the present study are that (1) acarbose accelerated wound healing and stimulated angiogenesis in T2DM, accompanied by improved BM-EPC functions (including tube formation, migration, and adhesion) and increased NO production and decreased O2− production in BM-EPCs; (2) in vitro, acarbose improved high glucose-mediated EPC dysfunction and enhanced intracellular NO level and impeded increased O2−; and (3) the beneficial effects of acarbose were mediated at least in part through activation of Akt/eNOS signaling. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.