NFKB1 and diabetes mellitus: The present study also demonstrated diabetes increased renal proteasomal activity, companied by the decrease in IκB and increase in NF-κB. MG132 treatment significantly inhibited proteasomal activity, companied by the upregulation of IκB and downregulation of NF-κB. It is widely accepted that inflammation contributes to the pathogenesis and progression of DN.