NFE2L2 and liver dysplastic nodule: The present study is the first to demonstrate that MG132 attenuates DN via suppression of proteasomal activity of diabetic kidney, which promotes degradation of Nrf2 and IκB. We set up diabetic mouse model with multiple low-dose streptozotocin in both wild-type and Nrf2-KO mice and treated with MG132 for 4 months.