It was shown that metformin decreases the expression of anti-apoptotic proteins B-cell lymphoma- 2 (BCL-2), B-cell lymphoma-extra-large (Bcl-Xl) and Myeloid cell leukemia-1 (Mcl-1), resulting to induction of the pro-apoptotic proteins, BCL2-Associated X Protein (BAX) and Bcl-2-Associated Death promoter (BAD) which lead to activation of caspases and apoptosis in Ovarian Cancer (OC) [54]. This evidence concerns the gene BAX and ovarian carcinoma.