CALCA and metabolic dysfunction-associated steatohepatitis: Additionally, IFN-γ-producing DX5+NKp46+ cNK cells are increased during non-alcoholic steatohepatitis (NASH), a cause of fibrosis, and skew the polarization of activated KC and liver macrophages toward an M1 profile, rather than toward a fibrosis-inducing M2 macrophage profile (60).