As depicted in Figure 5A, the suppressive function of CD28− Treg-like cells from RA patients was compromised compared to that of CD28+ Tregs [median reduction of proliferation of stimulated non-Tregs: −2.2% (−8.7.1 to 77.7) vs. 32.7% (−0.4 to 77.9); p = 0.008]. The gene discussed is CD28; the disease is rheumatoid arthritis.