In addition an algorithm using concentrations of three biomarkers TNFR1, soluble IL-33 receptor (ST2), and Reg3α, Levine and colleagues (65) were able to calculate the probability of non-relapse mortality caused by non-responsive GvHD and divide the patients into distinct groups to predict response to GvHD therapy. Here, TNFRSF1A is linked to graft versus host disease.