BIN1 and early-onset autosomal dominant Alzheimer disease: In contrast, late onset Alzheimer’s disease (LOAD) has been associated with other genes including apolipoprotein E-ε4 (APOE ε4), bridging integrator 1 (BIN1) region, clusterin (CLU), phosphatidylinositol clathrin assembly lymphoid-myeloid (PICALM), and complement receptor 1, mostly identified through genome-wide association studies (GWAS) (http://www.alzgene.org/).