NGRN and Alzheimer disease: In the same study by Hellwig et al. discussed above, CSF NGRN was found to have an AUC value of 0.85 when distinguishing AD from non-AD dementia subjects, suggesting that it may be more valuable diagnostically than YKL-40, and that it may also have the potential to distinguish different neuronal disorders, just like YKL-40 (78).