A couple of additional genetic markers have also been accorded relatively high ORs in the earlier GWAS studies (http://www.alzgene.org/), as well as a more recent meta-analysis (32), including BIN1, CLU, and PICALM. The BIN1 variant rs6733839 (OR of 1.22; meta p-value of 6.9 × 10−44) (32) and an additional variant (rs59335482; an insertion of 3 cytosine bases) ~28 kb upstream of BIN1 have been associated with increased AD risk (OR of 1.20; p-value of 3.8 × 10−11) (33). Here, BIN1 is linked to Alzheimer disease.