These results suggest that AD genes might influence different cognitive domains, but this appears to be in conflict with the 2013 study by Vos et al. particularly for APOE ε4, where Vos et al. reported that the APOE ε4 gene exhibited similar sensitivity and specificity when predicting the development of AD from naMCI and aMCI (Table 1). This evidence concerns the gene APOE and Alzheimer disease.