This report on the BiSS BD patients with a mean age of 52 years still finds the apparently over time consistent partial T cell deficit in showing reduced levels of lymphocytes and total CD3+ T cells also in the relatively old BiSS cohort, while the restoration within the CD4+ T-helper cells subset had further continued into an overshoot, showing significantly raised levels of Th2 and Th17 subpopulations, while Treg cells were reduced. The gene discussed is CD4; the disease is Behcet disease.