As our results indicated an involvement of Wnt antagonist sFRP4 in DG mediated apoptosis consistent with our earlier findings that sFRP4 addition chemosenstitizes glioma stem cells to drugs (Warrier et al., 2012; Bhuvanalakshmi et al., 2015), we were interested in examining how bCSCs over expressing sFRP4 would respond to DG. Here, SFRP4 is linked to central nervous system cancer.