As our results indicated an involvement of Wnt antagonist sFRP4 in DG mediated apoptosis consistent with our earlier findings that sFRP4 addition chemosenstitizes glioma stem cells to drugs (Warrier et al., 2012; Bhuvanalakshmi et al., 2015), we were interested in examining how bCSCs over expressing sFRP4 would respond to DG. This evidence concerns the gene SFRP4 and glioma.