COX16 and Alzheimer disease: Interestingly, five O. degus DEGs could be linked to AD-related genes in all subjects (overall correlation) this included COX16, APOC1, ITGBL1, FGF9, and AMD1. All five DEGs correlated with MMSE scores, while three: ITGBL1, FGF9, and AMD1 were both MMSE and NFT-correlated.