APP and Alzheimer disease: Furthermore, Deacon et al. (2015) shows that AD-like O. degus have high levels of Aβ-peptide aggregates, APP, TNF-a, IL-6, IFN-a, and the oxidative stress marker NFE2L2 when compared to healthy control O. degus, suggesting that AD-like O. degus present increased inflammation as is observed in human AD patients (Deacon et al., 2015).