The prion protein, often referred to as cellular prion protein (PrPC) was discovered amid studies of transmissible spongiform encephalopathies (TSEs), such as Creutzfeldt-Jakob Disease, a low-prevalence, mostly sporadic, fatal and still incurable neurodegenerative disease (Takada and Geschwind, 2013). The gene discussed is PRNP; the disease is neurodegenerative disease.