PRNP and early-onset autosomal dominant Alzheimer disease: Whereas misfolding of PrPC is usually considered the major, if not indispensable requirement for neurodegeneration in TSEs, experimental work indicated that the normal PrPC conformer serves as a binding site for diffusible Aß peptide oligomers (AßO) in the course of Alzheimer’s Disease (AD; Um and Strittmatter, 2013; Laurén, 2014; Kostylev et al., 2015).