PRNP and demyelinating polyneuropathy: On the other hand, the recently disclosed interaction in trans of the N-terminal flexible tail of PrPC with the Adhesion G protein-coupled receptor Gpr126 was shown to favor myelination of peripheral axons through an increase in the levels of cAMP in Schwann cells, which likely explains the demyelinating polyneuropathy that affects aging PrPC-null mice (Küffer et al., 2016).