DISC1 and schizophrenia: Furthermore a rare mutation in KATNAL1 has been associated with schizophrenia10 (http://atgu.mgh.harvard.edu/~spurcell/genebook/genebook.cgi?user=guest&cmd=verb-gene&tbox=KATNAL1) and KATNAL1 has been shown to interact with the schizophrenia associated gene DISC1.33 In line with these observations we note that increases in ventricular volume and reductions in synaptic spines have been reported in schizophrenic patients34, 35 and our data demonstrates the same phenotypes in Katnal11H/1H mice.