The role of tumor stroma has long been shown to promote tumor growth and invasiveness either via direct cell–cell interaction, through the secretion of tumor‐promoting cytokines such as hepatocyte growth factor (HGF) and transforming growth factor beta (TGFβ), or by modulating extracellular matrix components via integrins or fibroblast growth factors (Liu et al, 2011; Desert et al, 2016; Affo et al, 2017). This evidence concerns the gene TGFB1 and neoplasm.