APOA1 and atherosclerosis: In addition, pharmacological strategies that target apoA-I, including the upregulation of its production with the bromodomain and extraterminal protein inhibitor RVX-208, the development of short peptide sequences that mimic its action, and its administration as a component of reconstituted HDL-C (containing apoA-I as its only protein and a phospholipid as its only lipid) have beneficial effects on inflammatory factors that are known to be involved in atherosclerosis and plaque stability [16, 22].