The observation that the estimated SCD activity was directly correlated with SAT and total body fat, but not VAT (although with trunk fat), is partly congruent with previous observational studies in elderly or middle-aged subjects, showing positive associations with fat mass and obesity [23, 33, 34], VAT thickness [22] and to obesity-related diseases [16, 46–48]. Here, SCD is linked to obesity due to melanocortin 4 receptor deficiency.