While the primary effect of iron deficiency is the development of anemia and its related consequences (e.g., fatigue, decreased exercise capacity, and reduced quality of life), iron deficiency is also associated with other adverse effects, including cardiac dysfunction [5, 6] and exacerbation of restless legs syndrome [7], possibly related to impairments in the generation of cellular energy and oxygen storage in myoglobin in heart and skeletal muscle [2, 4, 8]. The gene discussed is MB; the disease is Iron deficiency anemia.