MKI67 and ductal breast carcinoma in situ: Taking together the tumours clinico-pathological parameters and CAFs’ gene expression profiling it is tempting to assume that despite aggressive features such as big tumour size, high Ki67 status and vascular invasion, that the presence of DCIS, absence of lymph node metastasis and lack of chemotactic “secretory type II CAFs” marks the onset of a spreading tumour which has not yet manifested.