Furthermore, a consistent correlation of PinX1 expression and BMP5 expression in two NSCLC cohorts, as well as the inhibition of noggin and the promotion of ectogenic BMP5 in vitro assay confirmed that BMP5 might be the key molecule contribute to PinX1-inhibited cell proliferation and cell cycle transition. This evidence concerns the gene PINX1 and non-small cell lung carcinoma.